rs57585902

This variant is located in the SLCO1B3 gene.

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ClinVar annotation

Likely Benign★★★☆
4 submitters2 publications

Rotor syndrome; not provided

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Research that mentions this SNP (1)

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The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients
AssociationN=54Sin-Chi Chew et al.(2011)· Cancer Chemotherapy and Pharmacology

This pharmacogenetic study of 54 Asian nasopharyngeal cancer patients examined how polymorphisms in CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2, and SLCO1B3 affect docetaxel pharmacokinetics and toxicity. Patients homozygous for the variant allele (GG) of SLCO1B3 rs11045585 had significantly higher AUC and lower clearance of docetaxel (P = 0.026 and P = 0.036, respectively). ABCB1 heterozygotes showed the highest decrease in nadir hemoglobin (P = 0.006). The study suggests functional polymorphisms in SLCO1B3 and ABCB1 cooperatively influence docetaxel disposition.

Traits studied:Docetaxel pharmacokineticsDocetaxel toxicityHematological toxicityNasopharyngeal carcinomaNon-hematological toxicity
PubMedDOIMetascience Observatory

About SLCO1B3

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity. [provided by RefSeq, Mar 2017]

View all SLCO1B3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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