rs581111

This is a intron variant variant in the OPRD1 gene.

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Research that mentions this SNP (1)

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The relationship between polymorphisms of BDNFOS and BDNF genes and heroin addiction in the Han Chinese population
ReviewTianbo Jin et al.(2016)· The Journal of Gene Medicine

This review examines neurogenetic and neuropharmacological correlates of opioid use disorder (OUD) with emphasis on ancestry-specific genetic risk profiles. The paper identifies multiple genes involved in the reward pathway (DRD2, DRD3, DRD4, OPRM1, OPRK1, OPRD1, BDNF, NRXN3, COMT, SLC6A4, KCNC1, KCNG2) and their variants associated with OUD susceptibility and treatment response across different ethnic populations, highlighting critical research disparities where African Americans and Hispanics have been underrepresented in genetic association studies.

Traits studied:Alcohol DependenceCocaine AddictionHeroin AddictionHeroin DependenceMethamphetamine DependenceMitochondrial DysfunctionNeonatal Abstinence SyndromeOpioid AddictionOpioid DependenceOpioid Use DisorderOxidative StressPain SensitivitySubstance Use Disorder
PubMedDOIMetascience Observatory

About OPRD1

Enables G protein-coupled enkephalin receptor activity. Involved in several processes, including G protein-coupled opioid receptor signaling pathway; cellular response to hypoxia; and positive regulation of peptidyl-serine phosphorylation. Located in plasma membrane. Implicated in alcohol dependence; alcohol use disorder; drug dependence (multiple); opioid abuse; and withdrawal disorder. Biomarker of opioid abuse. [provided by Alliance of Genome Resources, Apr 2025]

View all OPRD1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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