rs58231493

This variant is located in the HEATR4 gene.

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

metabolite measurement

Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele T
OR 0.81
p —
N 4,440
Large GWAS
European

undecenoylcarnitine (C11:1) measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele T
OR 0.25
p 7.0e-60
N 8,253
Large GWAS
European

X-21607 measurement

Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele T
OR 0.25
p 2.0e-55
N 4,540
Large GWAS
European

galanin peptides measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele T
OR 0.03
p 8.0e-15
N 47,745
Large GWAS
European

X-11308 measurement

Chen Y et al. “Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases.” Nature Genetics 55(1):44-53 (2023)
Allele T
OR 0.10
p 2.0e-10
N 8,253
Large GWAS
European

X-24588 measurement

Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele T
OR 0.09
p 6.0e-17
N 4,869
Large GWAS
European

About HEATR4

Predicted to enable oxidoreductase activity. [provided by Alliance of Genome Resources, Jul 2025]

View all HEATR4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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