rs59648931
This variant is located in the ROBO4 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
level of roundabout homolog 4 in blood serum
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.09
p 8.0e-41
N 47,745
Large GWAS
European
▶ClinVar annotation
Benign★★★☆
3 submitters1 publicationnot provided; Familial thoracic aortic aneurysm and aortic dissection
View on ClinVar →About ROBO4
Predicted to enable cell-cell adhesion mediator activity. Involved in establishment of endothelial barrier. Located in extracellular exosome. Implicated in aortic valve disease 3. Biomarker of pre-eclampsia and thyroid gland carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
View all ROBO4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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