rs59724122

This is a intron variant variant.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele T

OR 0.03

p 1.0e-135

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

social inhibition quality, attention deficit hyperactivity disorder, substance abuse

Karlsson Linnér R et al. “Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.” Nature Neuroscience 24(10):1367-1376 (2021)

Allele C

OR 0.01

p 4.0e-19

N 2,776,348

Large GWAS

European

bipolar disorder, schizophrenia, response to lithium ion

Amare AT et al. “Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.” Jama Psychiatry 75(1):65-74 (2018)

Allele T

OR —

p 5.0e-9

N 25,097,430

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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