rs5999924

This variant is located in the APOL6 gene.

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Research that mentions this SNP (1)

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Single nucleotide polymorphism associated with nonsyndromic cleft palate influences the processing of miR‐140
AssociationN=116Ling Li et al.(2010)· American Journal of Medical Genetics Part A

This case-control study of 57 children/adolescents with metabolic syndrome (MetS) and 59 controls examined five SNPs in the APOA5 gene's miRNA target sites. Only rs72525532 (c.*285_*286insGA) showed variation, with the AA insertion genotype significantly more frequent in MetS cases (12.28%) versus controls (1.7%, P=0.012) and associated with increased triglycerides and MetS risk (OR=8.12, P=0.05), though this association became non-significant after age adjustment (OR=5.66, P=0.124).

Traits studied:Blood pressureBody mass indexFasting blood glucoseHDL cholesterolLDL cholesterolMetabolic syndromeTotal cholesterolTriglycerides
PubMedDOIMetascience Observatory

About APOL6

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]

View all APOL6 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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