rs6005807

This is a intron variant variant in the TTC28 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

lymphocyte percentage of leukocytes

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)

Allele C

OR 0.02

p 1.0e-9

N 408,112

Large GWAS

European

ovarian serous carcinoma

Phelan CM et al. “Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.” Nature Genetics 49(5):680-691 (2017)

Allele C

OR 1.17

p 5.0e-9

N 54,990

Large GWAS

European

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Research that mentions this SNP (1)

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A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome‐wide significant common variants

AssociationN=25,537Sehee Kim et al.(2019)· International Journal of Cancer

A comprehensive gene-environment interaction study in ovarian cancer examining 28 genome-wide significant variants and 7 environmental risk factors (oral contraceptive use, parity, tubal ligation, breastfeeding, menopausal hormone therapy, BMI, endometriosis) in 9,971 cases and 15,566 controls. The strongest multiplicative interaction identified was between rs13255292 and OCP use (P = 3.48 × 10⁻⁴), with differential protective effects by genotype and duration of use, though no interactions remained significant after multiple testing correction.

Traits studied:Epithelial ovarian cancerFallopian tube cancerOvarian cancerPrimary peritoneal cancer

PubMed DOI Metascience Observatory

About TTC28

Enables kinase binding activity. Involved in regulation of mitotic cell cycle. Located in midbody. [provided by Alliance of Genome Resources, Jul 2025]