rs60134943
This is a upstream gene variant variant in the GSDMA gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
neutrophil count
Gagnon MF et al. “Interplay between hereditary and acquired factors determines the neutrophil counts in older individuals.” Blood Advances 7(13):3232-3243 (2023)
Allele T
OR 0.17
p 6.0e-10
N 2,465
Large GWAS
European
body composition measurement
Wu Z et al. “Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk.” Nature Communications 16(1):7490 (2025)
Allele T
OR 0.05
p 4.0e-11
N 39,007
Large GWAS
European
About GSDMA
Enables wide pore channel activity. Involved in defense response to bacterium and pyroptotic inflammatory response. Located in perinuclear region of cytoplasm. Is active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all GSDMA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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