rs6048205
This is a regulatory region variant variant in the LINC00261 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
glucose measurement
Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.05
p 1.0e-17
N 325,386
Major Consortium StudyLarge GWAS
multi-ancestry
blood glucose amount, body mass index
Manning AK et al. “A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.” Nature Genetics 44(6):659-69 (2012)
Allele A
OR —
β 0.002
p 2.0e-12
N 58,074
Large GWAS
European
blood glucose amount
Manning AK et al. “A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.” Nature Genetics 44(6):659-69 (2012)
Allele A
OR 0.03
p 6.0e-9
N 58,074
Large GWAS
European
sex hormone-binding globulin measurement
Ruth KS et al. “Using human genetics to understand the disease impacts of testosterone in men and women.” Nature Medicine 26(2):252-258 (2020)
Allele A
OR 0.01
p 4.0e-8
N 368,929
Large GWAS
European
About LINC00261
This gene produces a long non-coding RNA that acts as a negative regulator of cell growth. This transcript may promote differentiation and apoptosis. [provided by RefSeq, Dec 2017]
View all LINC00261 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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