rs6081541
This is a intron variant variant in the SLC24A3 gene.
▶Research that mentions this SNP (1)
▶Genome‐wide association study of atypical psychosisAssociationN=929Tetsufumi Kanazawa et al.(2013)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A GWAS of 47 Japanese atypical psychosis patients and 882 controls identified suggestive associations with CHN2/CPVL (rs245914, P=1.6×10⁻⁷), COL21A1 (rs12196860, P=2.45×10⁻⁷), and PYGL/TRIM9 (rs1959536, P=7.73×10⁻⁷), though none reached genome-wide significance. Gene-based analysis revealed significant genetic overlap with schizophrenia (P=0.014) but not bipolar disorder, suggesting atypical psychosis shares greater genetic architecture with schizophrenia.
About SLC24A3
Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008]
View all SLC24A3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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