rs6094237

This is a intergenic variant variant.

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

matrix metalloproteinase-9 measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele A
OR 0.11
p 2.0e-15
N 10,708
Large GWAS
European
▶

Research that mentions this SNP (1)

▶
Genetic variants in matrix metalloproteinase genes as disposition factors for ovarian cancer risk, survival, and clinical outcome
AssociationN=834Yan Wang et al.(2015)· Molecular Carcinogenesis

A case-control association study of 339 ovarian cancer cases and 349 controls examined 266 SNPs in 23 matrix metalloproteinase (MMP) genes. Four SNPs were significantly associated with ovarian cancer risk after multiple-comparison adjustment: rs2292730 (MMP20, OR=2.03, p=0.0002), rs6094237 (MMP9, OR=0.53), rs12278250 (MMP20, OR=0.50), and rs9787933 (MMP20, OR=0.50). Thirty-four SNPs were associated with overall survival, with rs2239008 (MMP1, HR=3.10) being most significant. One SNP (rs7826929 in MMP16) was associated with chemotherapy response. Gene-dosage effects and higher-order interactions were detected among top SNPs.

Traits studied:Chemotherapy responseOvarian cancer overall survivalOvarian cancer risk
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…