rs610932

A case-control study of 190 AD patients and 193 controls in the Chinese Han population found that the T allele of rs3865444 in CD33 (OR=0.480, p<0.001) and the C allele of rs610932 in MS4A6A (OR=0.622, p=0.001) are associated with increased Alzheimer's disease risk, confirming previous GWAS findings in a non-Caucasian population.

This comprehensive genome-wide association study examined genetic variants contributing to late-onset Alzheimer's disease (AD) in 513 African American cases and 496 controls, plus replication in 5 white cohorts. The APOE ε4 allele showed strong association (P=9.69×10⁻²³), and after adjusting for APOE, rs6859 in PVRL2 remained significantly associated (P=0.0087). The study found associations with variants in CLU, PICALM, BIN1, EPHA1, MS4A, ABCA7, and CD33, though effect directions sometimes differed from white populations. Novel associations with suggestive evidence were identified in PROX1, CNTNAP2, STK24, and other genes, though not replicated in whites.