rs61136219

This is a regulatory region variant variant in the SYDE2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

gut microbiome measurement, number of siblings

Stickley SA et al. “Gene-by-environment interactions modulate the infant gut microbiota in asthma and atopy.” The Journal of Allergy and Clinical Immunology 156(2):433-448 (2025)

Allele A

OR 1.08

p 5.0e-8

N 688

Small GWAS

multi-ancestry

About SYDE2

Predicted to enable GTPase activator activity. Acts upstream of or within cell migration. Predicted to be located in cytosol. Predicted to be active in synaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all SYDE2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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