rs613391
This variant is located in the LINC01239 gene.
▶Research that mentions this SNP (1)
▶A functional variant rs1537373 in 9p21.3 region is associated with pancreatic cancer riskAssociationN=5,523Beibei Zhu et al.(2019)· Molecular Carcinogenesis
A two-stage case-control study identified rs1537373 in the ANRIL long non-coding RNA gene region as associated with decreased pancreatic cancer risk (OR=0.82, 95% CI=0.75-0.90, p=1.051×10⁻⁵ in combined analysis of 1567 cases and 4956 controls). Functional assays demonstrated that rs1537373 influences enhancer activity through differential transcription factor binding and regulates CDKN2B gene expression (p=6.00×10⁻⁴ for eQTL), suggesting a mechanism by which this variant confers pancreatic cancer susceptibility.
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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