rs6135555

This is a intron variant variant in the MACROD2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

brain attribute

Sha Z et al. “The genetic architecture of structural left-right asymmetry of the human brain.” Nature Human Behaviour 5(9):1226-1239 (2021)

Allele A

OR —

p 7.0e-9

N 32,256

Large GWAS

European

About MACROD2

The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage. [provided by RefSeq, May 2017]

View all MACROD2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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