rs61738025

This variant is located in the LTBP2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

gut microbiome measurement, breastfeeding duration

Stickley SA et al. “Gene-by-environment interactions modulate the infant gut microbiota in asthma and atopy.” The Journal of Allergy and Clinical Immunology 156(2):433-448 (2025)
Allele T
OR —
β 0.040
p 3.0e-11
N 688
Small GWAS
multi-ancestry
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ClinVar annotation

Benign★★★☆
5 submitters2 publications

not specified; Glaucoma 3, primary congenital, D; Weill-Marchesani syndrome; not provided

View on ClinVar →

About LTBP2

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]

View all LTBP2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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