rs61751053
This is a protein-altering variant in the ARHGEF38 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
estrogen-receptor positive breast cancer
Jia G et al. “Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction.” Nature Genetics 56(5):819-826 (2024)
Allele T
OR 1.69
p 1.0e-10
N 28,328
Large GWAS
African American or Afro-Caribbean, Sub-Saharan African, African unspecified
breast cancer
Jia G et al. “Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction.” Nature Genetics 56(5):819-826 (2024)
Allele T
OR 1.48
p 1.0e-8
N 40,138
Large GWAS
African American or Afro-Caribbean, Sub-Saharan African, African unspecified
About ARHGEF38
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all ARHGEF38 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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