rs61882275

This is a downstream gene variant variant in the ELF5 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

polymeric immunoglobulin receptor measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.05
p 1.0e-23
N 47,745
Large GWAS
European

COVID-19

Pairo-Castineira E et al. “GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.” Nature 617(7962):764-768 (2023)
Allele A
OR 0.88
p 1.0e-22
N 1,779,771
Meta-analysisLarge GWAS
multi-ancestry
Kousathanas A et al. “Whole-genome sequencing reveals host factors underlying critical COVID-19.” Nature 607(7917):97-103 (2022)
Allele A
OR —
p 2.0e-8
N 55,891
Large GWAS
multi-ancestry

About ELF5

This gene encodes an epithelium-specific ETS family transcription factor. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. This gene has been implicated as a tumor suppressive transcription factor in breast cancer. [provided by RefSeq, May 2022]

View all ELF5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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