rs61921502
This is a intron variant variant in the MSRB3 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hippocampal volume
Hibar DP et al. “Novel genetic loci associated with hippocampal volume.” Nature Communications 8:13624 (2017)
Allele T
OR 9.02
p 2.0e-19
N 26,814
Large GWAS
multi-ancestry
Klein M et al. “Genetic Markers of ADHD-Related Variations in Intracranial Volume.” The American Journal of Psychiatry 176(3):228-238 (2019)
Allele T
OR 8.74
p 2.0e-18
N 24,704
Large GWAS
European
brain volume, hippocampal volume
Hibar DP et al. “Common genetic variants influence human subcortical brain structures.” Nature 520(7546):224-9 (2015)
Allele T
OR 39.90
p 7.0e-11
N 13,171
Large GWAS
multi-ancestry
amygdala volume
Ji Y et al. “Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes.” Nature Genetics 57(4):839-850 (2025)
Allele G
OR 0.08
p 2.0e-10
N 16,899
Large GWAS
European
About MSRB3
The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]
View all MSRB3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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