rs6214

A genome-wide association study (GWAS) of 506-937 bipolar affective disorder cases and 510-990 controls identified multiple SNPs in the IGF1 gene associated with bipolar disorder, with four SNPs showing p-values of 3.7×10⁻⁵, 8.4×10⁻⁴, 2.6×10⁻⁴, and 2.5×10⁻⁴. Resequencing identified novel variants in IGF1, including rs5742620 (p=0.0454) and rs78352613 (p=0.006) in the promoter region. Gene-wide analysis and haplotypic association confirmed IGF1 as a candidate susceptibility gene for bipolar disorder with dominant inheritance pattern.

This study examined associations between common genetic variants in the IGF1 gene and type 1 diabetes, childhood growth, and metabolism. Using resequencing and tag SNPs in 3,121 type 1 diabetes family trios and 902 children from the ALSPAC birth cohort, the authors found that IGF1 variants showed no association with type 1 diabetes (χ² p=0.356) and were not significantly associated with birthweight, childhood growth, or insulin secretion. However, IGF1 genetic variation was weakly associated with circulating IGF-1 concentrations at birth (R²=0.063, p=0.029) and marginally at age 7-8 years (R²=0.030, p=0.055).