rs62143197

This is a intron variant variant in the NLRP12 gene.

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GWAS Catalog Trait Associations (101)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cold-inducible RNA-binding protein measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.66
p 4.0e-120
N 3,301
Large GWAS
European

eukaryotic translation initiation factor 3 subunit G measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.61
p 3.0e-101
N 3,301
Large GWAS
European

40S ribosomal protein S3a measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.58
p 4.0e-91
N 3,301
Large GWAS
European

eukaryotic translation initiation factor 1A, X-chromosomal measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.58
p 3.0e-90
N 3,301
Large GWAS
European

uncharacterized protein KIAA0040 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.57
p 3.0e-88
N 3,301
Large GWAS
European

heterogeneous nuclear ribonucleoprotein A/B amount

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.57
p 7.0e-86
N 3,301
Large GWAS
European

dual specificity mitogen-activated protein kinase kinase 1 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.55
p 2.0e-81
N 3,301
Large GWAS
European

protein kinase c beta type (splice variant beta-II) measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.54
p 2.0e-78
N 3,301
Large GWAS
European

ribosomal protein S6 kinase alpha-6 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.53
p 8.0e-76
N 3,301
Large GWAS
European

peptidyl-prolyl cis-trans isomerase H measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.52
p 6.0e-72
N 3,301
Large GWAS
European

About NLRP12

This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

View all NLRP12 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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