rs62143198

This variant is located in the NLRP12 gene.

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GWAS Catalog Trait Associations (77)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

DNA-3-methyladenine glycosylase measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.73
p 3.0e-152
N 3,301
Large GWAS
European

arf-GAP domain and FG repeat-containing protein 1 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.70
p 3.0e-136
N 3,301
Large GWAS
European

heterogeneous nuclear ribonucleoprotein D-like measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.70
p 6.0e-135
N 3,301
Large GWAS
European

RNA-binding protein 3 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.70
p 1.0e-134
N 3,301
Large GWAS
European

clathrin interactor 1 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.69
p 5.0e-131
N 3,301
Large GWAS
European

regulator of microtubule dynamics protein 1 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.67
p 1.0e-124
N 3,301
Large GWAS
European

rho GDP-dissociation inhibitor 2 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.67
p 1.0e-121
N 3,301
Large GWAS
European

beta-adrenergic receptor kinase 1 measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.66
p 5.0e-120
N 3,301
Large GWAS
European

5-formyltetrahydrofolate cyclo-ligase measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.65
p 5.0e-116
N 3,301
Large GWAS
European

probable RNA-binding protein EIF1AD measurement

Sun BB et al. “Genomic atlas of the human plasma proteome.” Nature 558(7708):73-79 (2018)
Allele A
OR 0.65
p 2.0e-113
N 3,301
Large GWAS
European

About NLRP12

This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

View all NLRP12 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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