rs62189006

This is a intron variant variant in the SLC4A10 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

daytime rest measurement

Dashti HS et al. “Genetic determinants of daytime napping and effects on cardiometabolic health.” Nature Communications 12(1):900 (2021)
Allele A
OR 0.01
p 7.0e-10
N 452,633
Large GWAS
European

About SLC4A10

This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

View all SLC4A10 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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