rs62266876

This variant is located in the COPG1 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele G

OR 0.01

p 2.0e-15

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)

Allele G

OR 0.01

p 4.0e-8

N 1,122,049

Large GWAS

European

body weight

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele C

OR 0.05

p 2.0e-15

N 609,198

Major Consortium StudyLarge GWAS

multi-ancestry

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ClinVar annotation

Likely Benign★★★☆

3 submitters1 publication

not specified; Cholangiocarcinoma; Adrenocortical carcinoma, hereditary; Uveal melanoma; Colorectal cancer; Malignant lymphoma, large B-cell, diffuse

View on ClinVar →

About COPG1

Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Located in Golgi apparatus. Implicated in immunodeficiency 128. [provided by Alliance of Genome Resources, Jul 2025]