rs62479589

This variant is located in the CALU gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cartilage thickness measurement

Faber BG et al. “The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses.” Ebiomedicine 95:104759 (2023)

Allele A

OR 0.04

p 2.0e-8

N 50,745

Meta-analysisLarge GWAS

European

About CALU

The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

View all CALU variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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