rs62621193
This variant is located in the ARID4A gene.
▶ClinVar annotation
not provided; Colorectal cancer; Gastric cancer; Acute myeloid leukemia; Malignant tumor of esophagus; Lymphoma; Ovarian serous cystadenocarcinoma; Uterine carcinosarcoma; Thymoma; Thyroid cancer, nonmedullary, 1; Colon adenocarcinoma; Sarcoma; Melanoma; Hepatocellular carcinoma; Uterine corpus endometrial carcinoma; Clear cell carcinoma of kidney; Uveal melanoma; Nonpapillary renal cell carcinoma; Lung cancer; Cervical cancer; Familial cancer of breast
View on ClinVar →About ARID4A
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]
View all ARID4A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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