rs6294
This is a synonymous variant in the HTR1A gene — it does not change the protein's amino acid sequence.
▶Research that mentions this SNP (1)
▶Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disordersAssociationN=1,128Hettema JM et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This two-stage case-control association study examined four SNPs spanning the HTR1A gene (serotonin 1A receptor) in 589 cases and 539 controls selected for extreme genetic risk of depression and anxiety disorders. Although rs1364043 showed nominally significant association in stage 1 (P<0.1), this failed to replicate in stage 2, and multi-marker haplotypes including the previously implicated C(-1019)G promoter polymorphism (rs6295) showed no consistent associations. The findings suggest HTR1A genetic variation alone is unlikely to contribute substantially to genetic susceptibility to depressive and anxiety-related phenotypes.
About HTR1A
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]
View all HTR1A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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