rs6332
This is a synonymous variant in the NTF3 gene — it does not change the protein's amino acid sequence.
▶Research that mentions this SNP (2)
▶Neurotrophic factor‐related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high‐risk male populationAssociationN=143Conner AC et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A candidate gene association study examined six SNPs in neurotrophic factor genes (NTF3, NTRK2, NTRK3, BDNF, p75NTR) for association with adult ADHD scores in 143 high-risk males from a forensic psychiatric unit. While no SNPs showed significant association after Bonferroni correction, rs6332 in NTF3 exon III showed a trend toward association with increased ADHD scores (P=0.05 for WURS-k; P=0.03 for Wender-Reimherr interview), suggesting the A-allele may be a potential risk factor.
▶An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHDAssociationN=240Zahoor Syed et al.(2007)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This candidate gene association study examined 10 SNPs across three neurotrophic factor genes (GDNF, NGF, and NT3) in 120 ADHD probands and their biological parents, plus 120 controls. The non-synonymous SNP rs6330 in NGF (coding alanine/valine change) showed borderline significant overtransmission of the C allele in family-based analysis (Chi-square = 3.69, OR = 1.65, P = 0.05), though this finding was not replicated in case-control analysis and may represent a Type I error.
About NTF3
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
View all NTF3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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