rs642043

This is a intergenic variant variant in the SPRY3 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroimaging measurement

Jiang Z et al. “The X chromosome's influences on the human brain.” Science Advances 11(4):eadq5360 (2025)

Allele T

OR 6.43

p 1.0e-10

N 37,772

Large GWAS

European

About SPRY3

Involved in negative regulation of MAPK cascade. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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