rs6435017
This is a intron variant variant in the SATB2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
dyslexia
Doust C et al. “Discovery of 42 genome-wide significant loci associated with dyslexia.” Nature Genetics 54(11):1621-1629 (2022)
Allele T
OR 0.96
p 5.0e-9
N 1,138,870
Large GWAS
European
About SATB2
This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]
View all SATB2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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