rs6449693

This is a downstream gene variant variant in the HTR1A gene.

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Research that mentions this SNP (1)

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The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder
Meta-analysisN=9,732Taro Kishi et al.(2013)· European Archives of Psychiatry and Clinical Neuroscience

Meta-analysis of 15 studies (4,297 patients, 5,435 controls) found that the serotonin 1A receptor gene (HTR1A) SNPs rs6295 (C-1019G) and rs878567 are significantly associated with mood disorders and major depressive disorder. The rs6295 G allele was protective against mood disorders (OR = 0.87, 95% CI 0.79-0.96, P = 0.007 in allele model), with stronger effects in Asian populations (OR = 0.81, P = 0.0007). rs878567 also showed protective association with mood disorders (OR = 0.83, P = 0.0002).

Traits studied:Affective disordersAnxiety disordersBipolar disorderMajor depressive disorderMood disordersNeuroticism
PubMedDOIMetascience Observatory

About HTR1A

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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