rs6478746
This is a downstream gene variant variant.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
glaucoma
Xue Z et al. “Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank.” Ebiomedicine 82:104161 (2022)
Allele G
OR 0.14
p 2.0e-13
N 68,390
Meta-analysisMajor Consortium StudyLarge GWAS
European
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.15
p 9.0e-12
N 394,626
Large GWAS
European
optic cup area, open-angle glaucoma
Gharahkhani P et al. “Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma.” Scientific Reports 8(1):3124 (2018)
Allele G
OR —
p 5.0e-8
N 39,649
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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