rs6488162

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

heart rate response to exercise

Verweij N et al. “Genetic study links components of the autonomous nervous system to heart-rate profile during exercise.” Nature Communications 9(1):898 (2018)

Allele T

OR 0.07

p 3.0e-30

N 58,818

Large GWAS

multi-ancestry

heart rate variability measurement

Tegegne BS et al. “Phenotypic but not genetically predicted heart rate variability associated with all-cause mortality.” Communications Biology 6(1):1013 (2023)

Allele T

OR 0.42

p 2.0e-26

N 46,075

Large GWAS

European

left ventricular stroke volume measurement

Schmidt AF et al. “Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.” Science Advances 9(17):eadd4984 (2023)

Allele T

OR —

p 2.0e-10

N 32,528

Large GWAS

European

heart rate response to recovery post exercise

Verweij N et al. “Genetic study links components of the autonomous nervous system to heart-rate profile during exercise.” Nature Communications 9(1):898 (2018)

Allele T

OR 0.10

p 2.0e-57

N 58,818

Large GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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