rs6501455

This is a upstream gene variant variant.

▶

GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

peak expiratory flow

Shrine N et al. “New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.” Nature Genetics 51(3):481-493 (2019)

Allele A

OR 0.04

p 2.0e-47

N 321,047

Large GWAS

European

Shrine N et al. “Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.” Nature Genetics 55(3):410-422 (2023)

Allele A

OR 14.03

p 1.0e-44

N 406,020

Large GWAS

multi-ancestry

forced expiratory volume

Allele A

OR 0.03

p 1.0e-36

N 321,047

Large GWAS

European

chronic obstructive pulmonary disease

Cosentino J et al. “Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models.” Nature Genetics 55(5):787-795 (2023)

Allele A

OR 0.02

p 2.0e-22

N 325,027

Large GWAS

European

vital capacity

Allele A

OR 0.02

p 7.0e-19

N 321,047

Large GWAS

European

FEV/FVC ratio

Allele A

OR 0.02

p 6.0e-18

N 321,047

Large GWAS

European

▶

Research that mentions this SNP (1)

▶

GWAS SNP Replication among African American and European American men in the North Carolina–Louisiana prostate cancer project (PCaP)

AssociationN=3,484Zongli Xu et al.(2011)· The Prostate

This GWAS replication study evaluated 800 SNPs in African American (n=417) and European American (n=455) prostate cancer cases versus controls (n=925 AA, n=1,687 EA) from the NC-LA Prostate Cancer Project. Of 32 European-based GWAS SNPs, 13 were significant at P<0.05 in European Americans and 4 in African Americans (rs6983267, rs7017300, rs1859962, rs6501455). Two additional SNPs reached study-wide significance: rs1472606 (OR=1.43 in EA) and rs9351265 (OR=1.48 in AA). The study confirms a large proportion of cancer-associated regions from European GWAS but shows limited predictive value (AUC=0.60 in EA, 0.56 in AA) for clinical screening.

Traits studied:Prostate cancer

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs6501455

GWAS Catalog Trait Associations (5)

peak expiratory flow

forced expiratory volume

chronic obstructive pulmonary disease

vital capacity

FEV/FVC ratio

Research that mentions this SNP (1)

Community Wiki

Comments