rs6503075

This variant is located in the ALOX12B gene.

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ClinVar annotation

Benign★☆☆☆
1 submitter
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Research that mentions this SNP (1)

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Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China
AssociationN=244Min Shen et al.(2009)· Environmental and Molecular Mutagenesis

A case-control study of 122 cases and 122 controls in Xuanwei, China examined 1,173 SNPs in 149 innate immunity gene regions for associations with lung cancer risk in a population exposed to high levels of coal smoke. FCER2 rs7249320 showed the strongest association (OR=0.30, 95% CI: 0.16-0.55, P<0.0001), while KLK2 rs2739476 and ALOX12B rs6503075 showed >2-fold increased risk. Significant interactions were found between KLK15 rs3745523 and coal exposure, and between FCER2 rs7249320 and KLK2 rs2739476 (OR=10.77, P=0.003).

Traits studied:Lung cancer
PubMedDOIMetascience Observatory

About ALOX12B

This gene encodes an enzyme involved in the conversion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq, Sep 2015]

View all ALOX12B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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