rs6503905
This is a synonymous variant in the SMG8 gene — it does not change the protein's amino acid sequence.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
myeloperoxidase measurement
Reiner AP et al. “Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.” Human Molecular Genetics 22(16):3381-93 (2013)
Allele A
OR 0.06
p 3.0e-12
N 9,260
Major Consortium StudyLarge GWAS
European
About SMG8
Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and regulation of protein kinase activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
View all SMG8 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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