rs6557168

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

suicidal ideation, suicide behaviour

Kimbrel NA et al. “Identification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans.” Jama Psychiatry 80(2):135-145 (2023)
Allele T
OR —
p 3.0e-12
N 633,778
Large GWAS
multi-ancestry

anxiety measurement

Levey DF et al. “Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program.” The American Journal of Psychiatry 177(3):223-232 (2020)
Allele C
OR —
p 1.0e-9
N 199,611
Major Consortium StudyLarge GWAS
multi-ancestry

suicidal ideation

Ashley-Koch AE et al. “Genome-wide association study identifies four pan-ancestry loci for suicidal ideation in the Million Veteran Program.” Plos Genetics 19(3):e1010623 (2023)
Allele C
OR 0.03
p 2.0e-8
N 612,381
Major Consortium StudyLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer
AssociationN=4,470Miriam S. Udler et al.(2009)· International Journal of Cancer

This population-based study of 4,470 breast cancer cases from the SEARCH cohort examined associations between germline polymorphisms in 6 steroid hormone metabolism genes (COMT, CYP19A1, ESR1, PGR, SULT1E1, STS) and survival after breast cancer diagnosis. A COMT polymorphism (rs4818) showed significant association with survival in a dominant model (HR=0.80, 95% CI: 0.69-0.95, p=0.009), though this was only marginally significant after permutation adjustment (p=0.047). No significant associations were found in the other genes studied.

Traits studied:All-cause mortalityBreast cancer prognosisBreast cancer recurrenceBreast cancer survivalBreast cancer-specific mortality
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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