rs6567416

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of serpin B8 in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.07
p 2.0e-21
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping
AssociationN=2,056Caitrin W. McDonough et al.(2009)· Human Genetics

This linkage and association study examined chromosome 18q21.1-23 in 223 African American families with diabetic nephropathy (DN). Fine mapping with SNPs revealed ordered subset analysis evidence for linkage (LOD 3.9, Δ P=0.0161, NPL P=0.00002) in families with earlier diabetes diagnosis. Dense SNP mapping in 1,029 DN cases and 1,027 controls identified NEDD4L (rs512099, P=0.0006, OR=0.70) and SERPINB7 (rs1720843, P=0.0017, OR=0.65) as candidate susceptibility genes for diabetic nephropathy in African Americans.

Traits studied:Chronic renal failureDiabetic nephropathyEnd-stage renal diseaseType 2 diabetes mellitus
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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