rs6590611
This variant is located in the NTM gene.
▶Research that mentions this SNP (1)
▶Identification of polymorphisms in ultraconserved elements associated with clinical outcomes in locally advanced colorectal adenocarcinomaAssociationN=662Moubin Lin et al.(2012)· Cancer
This study evaluated 48 SNPs within ultraconserved elements in 662 colorectal cancer patients to identify genetic variants associated with clinical outcomes in those receiving fluoropyrimidine-based adjuvant chemotherapy. Eight SNPs were significantly associated with recurrence or survival outcomes when stratified by disease stage. In stage II patients, rs7849 showed consistent increased recurrence risk across training (HR 2.39), validation (HR 3.70), and meta-analysis (HR 2.89). For stage III patients, rs6124509 and rs11195893 showed protective effects (HR 0.38 and 0.26 respectively), while rs10211390 increased recurrence risk (HR 2.70).
About NTM
This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
View all NTM variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…