rs659964

This is a intron variant variant in the ACAD10 gene.

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Research that mentions this SNP (1)

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Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians
AssociationN=7,224Bian L. et al.(2010)· Diabetologia

This study identified variants in ACAD10 associated with type 2 diabetes in Pima Indians and American Indians. SNP rs659964 showed the strongest association (p=0.0006, OR=1.28 in Pima; p=0.00007 combined) and rs601663 showed modest association (p=0.04, OR=1.14 in Pima; p=0.009 combined). The risk alleles were associated with reduced lipid oxidation rates and increased insulin resistance, supporting the hypothesis that ACAD10 variation increases diabetes susceptibility through impaired insulin sensitivity via abnormal lipid metabolism.

Traits studied:Adipocyte sizeBasal lipolysisGlucose toleranceInsulin resistanceLipid oxidationType 2 diabetes
PubMedDOIMetascience Observatory

About ACAD10

This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]

View all ACAD10 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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