rs660652

This is a downstream gene variant variant in the CHRNA3 gene.

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Research that mentions this SNP (1)

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Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity
AssociationN=505Erlich PM et al.(2010)· Human Genetics

This genetic association study examined 505 opioid-dependent patients and found that nicotinic acetylcholine receptor (nAChR) gene variants on chromosome 15q25.1 are associated with both nicotine dependence severity and opioid dependence severity. The CHRNA5 coding variant rs16969968[A] was significantly associated with 1.4-unit higher opioid dependence severity (p < 0.00017), while CHRNA3 variant rs660652[G] was associated with 1.7-fold higher smoking odds and 1.1-unit higher nicotine dependence (p < 0.0007). These findings extend the known role of the 15q25.1 locus from nicotine to prescription opioid dependence phenotypes.

Traits studied:Attempts to quit smokingNicotine dependence severityOpioid dependence severitySmoking quantitySmoking status
PubMedDOIMetascience Observatory

About CHRNA3

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

View all CHRNA3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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