rs66815886
This is a intron variant variant in the ADAMTS9-AS2 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
BMI-adjusted waist-hip ratio
Ng MCY et al. “Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.” Plos Genetics 13(4):e1006719 (2017)
Allele G
OR 0.06
p 9.0e-27
N 20,384
Major Consortium StudyLarge GWAS
multi-ancestry
type 2 diabetes mellitus
Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)
Allele G
OR 0.04
p 1.0e-21
N 1,407,282
Meta-analysisLarge GWAS
multi-ancestry
Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)
Allele G
OR 0.04
p 4.0e-14
N 6,710,881
Meta-analysisLarge GWAS
multi-ancestry
Mahajan A et al. “Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.” Nature Genetics 54(5):560-572 (2022)
Allele G
OR 0.05
p 9.0e-13
N 251,740
Large GWAS
European
leukocyte quantity
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele T
OR 0.01
p 4.0e-11
N 928,679
Large GWAS
multi-ancestry
subcutaneous adipose tissue quality
Ahmed A et al. “MRI-Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites.” Journal of Obesity 2025:7792701 (2025)
Allele T
OR 0.04
p 1.0e-9
N 37,589
Large GWAS
European
About ADAMTS9-AS2
Implicated in diabetic retinopathy. [provided by Alliance of Genome Resources, Jul 2025]
View all ADAMTS9-AS2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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