rs67027895

This variant is located in the AKT3 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroimaging measurement

Bhatt RR et al. “The Genetic Architecture of the Human Corpus Callosum and its Subregions.” Nature Communications 16(1):9708 (2025)
Allele T
OR 1.39
p 2.0e-12
N 46,685
Large GWAS
European

body height

Fang H et al. “Harmonizing Genetic Ancestry and Self-identified Race/Ethnicity in Genome-wide Association Studies.” American Journal of Human Genetics 105(4):763-772 (2019)
Allele T
OR —
β 0.050
p 2.0e-8
N 345,563
Large GWAS
multi-ancestry

About AKT3

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

View all AKT3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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