rs6707646

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cognitive domain measurement

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele C
OR 0.03
p 1.0e-13
N 158,996
Large GWAS
European
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Research that mentions this SNP (1)

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The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and Cerebrospinal Fluid Biomarker Levels
MethodsN=30,717Brit-Maren M. Schjeide et al.(2011)· Archives of General Psychiatry

This paper presents a novel bioinformatics method combining Gene Ontology (GO) with stratified false discovery rate (sFDR) analysis to prioritize genes for imaging genetics studies. Applied to ENIGMA2 GWAS meta-analysis data of hippocampal volume (N=30,717 individuals, 6,570,616 SNPs), the transport system gene network identified SNPs with sFDR q-values between 10-20%, including rs117831534 and rs118025365 in TESC (p=4.91e-07 and 4e-07), and multiple SNPs in SLC4A10 and KCNH7. The method demonstrates improved statistical power for discovering imaging genetic biomarkers without excessive multiple testing burden.

Traits studied:Alzheimer's diseaseHippocampal volume
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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