rs6735739

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

acne

Mitchell BL et al. “Genome-wide association meta-analysis identifies 29 new acne susceptibility loci.” Nature Communications 13(1):702 (2022)
Allele T
OR 1.07
p 4.0e-8
N 615,396
Meta-analysisLarge GWAS
European
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Research that mentions this SNP (1)

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A broad analysis of IL1 polymorphism and rheumatoid arthritis
AssociationN=6,623Alyssa K. Johnsen et al.(2008)· Arthritis &amp; Rheumatism

A comprehensive case-control and longitudinal cohort study of IL1A and IL1B polymorphisms in rheumatoid arthritis (RA) involving 3,561 patients and 3,062 controls across multiple populations. Despite strong suggestive findings in the discovery NARAC sample (RA3/A OR 1.27, P = 0.0021; RA4/C OR 1.56, P = 0.036), these associations failed replication in independent case-control cohorts and erosion status analyses, leading to the conclusion that common variants in IL1A/B do not significantly contribute to RA susceptibility or severity in European-descent populations.

Traits studied:Anti-cyclic citrullinated peptide antibodiesDisease Activity Score in 28 jointsDisease severity in rheumatoid arthritisRadiographic erosions in rheumatoid arthritisRheumatoid arthritis susceptibilityRheumatoid factor
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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