rs6755784
This variant is located in the TTN-AS1 gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
left ventricular systolic function measurement
Tadros R et al. “Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.” Nature Genetics 53(2):128-134 (2021)
Allele G
OR 1.45
p 2.0e-17
N 19,260
Large GWAS
European
heart function attribute
Tadros R et al. “Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.” Nature Genetics 53(2):128-134 (2021)
Allele G
OR 0.30
p 5.0e-14
N 19,260
Large GWAS
European
left ventricular mass
Tadros R et al. “Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.” Nature Genetics 53(2):128-134 (2021)
Allele G
OR 1.09
p 4.0e-13
N 19,260
Large GWAS
European
left ventricular diastolic function measurement
Tadros R et al. “Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.” Nature Genetics 53(2):128-134 (2021)
Allele G
OR 1.99
p 1.0e-11
N 19,260
Large GWAS
European
left ventricular ejection fraction measurement
Tadros R et al. “Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect.” Nature Genetics 53(2):128-134 (2021)
Allele G
OR 0.46
p 4.0e-10
N 19,260
Large GWAS
European
heart failure
Enzan N et al. “Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.” Nature Communications 16(1):9680 (2025)
Allele C
OR 0.02
p 1.0e-9
N 1,366,492
Large GWAS
European
About TTN-AS1
This gene encodes a non-coding RNA transcribed from the opposite strand to the titin gene. [provided by RefSeq, Aug 2016]
View all TTN-AS1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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