rs67579710
This is a upstream gene variant variant in the THBS3 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
protein measurement
Western D et al. “Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease.” Nature Genetics 56(12):2672-2684 (2024)
Allele A
OR 0.41
p 3.0e-32
N 3,506
Large GWAS
European
COVID-19
Pairo-Castineira E et al. “GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.” Nature 617(7962):764-768 (2023)
Allele A
OR 0.87
p 2.0e-22
N 2,974,917
Meta-analysisLarge GWAS
multi-ancestry
“A first update on mapping the human genetic architecture of COVID-19.” Nature 608(7921):E1-E10 (2022)
Allele A
OR 0.82
p 9.0e-12
N 1,786,021
Large GWAS
multi-ancestry
body fat percentage
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.02
p 2.0e-16
N 394,642
Large GWAS
European
gastric carcinoma
Hess T et al. “Dissecting the genetic heterogeneity of gastric cancer.” Ebiomedicine 92:104616 (2023)
Allele G
OR 1.21
p 6.0e-13
N 16,814
Large GWAS
European
About THBS3
The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]
View all THBS3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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