rs6762208
This variant is located in the SENP2 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body mass index
Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)
Allele C
OR 0.01
p 1.0e-14
N 1,122,049
Large GWAS
European
diastolic blood pressure
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.01
p 1.0e-13
N 928,679
Large GWAS
multi-ancestry
type 2 diabetes mellitus
Mahajan A et al. “Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.” Nature Genetics 50(4):559-571 (2018)
Allele A
OR 1.03
p 3.0e-8
N 452,244
Large GWAS
multi-ancestry
QRS duration
Prins BP et al. “Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.” Genome Biology 19(1):87 (2018)
Allele A
OR 0.31
p 5.0e-11
N 77,898
Meta-analysisLarge GWAS
European
▶ClinVar annotation
Benign★★★☆
2 submitters1 publicationAbout SENP2
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
View all SENP2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…