rs6773957

A case-control study of 443 T2D cases and 532 controls from a Russian population (HAPIEE cohort) investigating four polymorphisms as predictors of type 2 diabetes development over 10 years. rs7903146 in TCF7L2 was significantly associated with T2D risk (TT genotype RR 3.90, 95% CI 2.31-6.61; TC genotype RR 1.86, 95% CI 1.42-2.43; CC protective RR 0.37, 95% CI 0.29-0.49, all p<0.001). No significant associations were found for rs1799883 (FABP2), rs2237892 (KCNQ1), or rs6773957 (ADIPOQ). TCF7L2 rs7903146 retained significance in risk models for both men and women.

This case-control study of 1,028 endometrial cancer cases and 1,932 controls from Shanghai evaluated 87 SNPs in five obesity-related genes (ADIPOQ, ADIPOR1, ADIPOR2, LEP, LEPR). Three ADIPOQ SNPs (rs3774262 OR=0.68, rs1063539 OR=0.66, rs12629945) and one LEP SNP (rs2071045 OR=0.70) were significantly associated with reduced endometrial cancer risk. The ADIPOQ variants were also associated with lower body weight, waist circumference, and BMI in controls, suggesting a potential mechanism through obesity.

Family-based study of 634 non-diabetic individuals examining the ADIPOQ gene and albuminuria. rs17300539 in the ADIPOQ promoter was significantly associated with albumin-creatinine ratio (ACR, p=0.0027) and explained 4% of variance, and with HMW adiponectin levels (β=0.26, p=4.8×10⁻⁵). Variance component analysis showed ACR heritability of h²=0.20 and positive genetic correlation with HMW adiponectin (ρg=0.38, p=0.04), suggesting ADIPOQ variants modulate albuminuria levels.