rs680379

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (20)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of ceramide

Harshfield EL et al. “Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.” Bmc Medicine 19(1):232 (2021)
Allele A
OR 0.15
p 4.0e-45
N 13,814
Large GWAS
European
Cadby G et al. “Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.” Nature Communications 13(1):3124 (2022)
Allele A
OR 0.18
p 3.0e-15
N 4,492
Large GWAS
European

level of phosphatidylcholine

Harshfield EL et al. “Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.” Bmc Medicine 19(1):232 (2021)
Allele A
OR 0.14
p 2.0e-34
N 13,814
Large GWAS
European
Lotta LA et al. “A cross-platform approach identifies genetic regulators of human metabolism and health.” Nature Genetics 53(1):54-64 (2021)
Allele A
OR 8.34
p 8.0e-17
N 16,839
Large GWAS
European

sphingolipid level

Hicks AA et al. “Genetic determinants of circulating sphingolipid concentrations in European populations.” Plos Genetics 5(10):e1000672 (2009)
Allele A
OR 0.10
p 8.0e-15
N 4,110
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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